Verapamil is a calcium channel blocker, it treats high blood pressure relaxing and widening blood vessels.

(except WPW syndrome), sinus tachycardia, premature atrial contraction,
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Verapamil dose and route. A new trial involving 7,250 patients with Parkinson's disease (PD), which could not be done because the patients were not yet eligible, could find any benefit when compared with placebo, according to a new article published in The Lancet Neurol. (Related: "Study Finds 'Miracle' Migraine Drugs May Make Patients Less Vulnerable to Parkinson's.") These clinical trials could help clarify the question of why drugs were effective while placebo was only slightly better, or not much better at all, in controlling PD. "For this type of study, placebo is a completely inadequate measure to assess effectiveness," said lead author J. Matthew Walker (no relation), associate professor of neurology at Boston University School of Medicine. "Even if placebo was effective, it's not a good surrogate measure for long-term medication use. So there's this opportunity here to try and measure the effect of drug in this patient population." [5 Everyday Things You Should Know About the Brain] In this study, patients with Parkinson's disease were randomly assigned to receive either the drug riluzole, known as ATX102, in tablet form, the primary treatment or placebo. Patients were monitored for a year after starting the treatment. While placebo arm showed no difference, the results didn't seem to hold up after one year. Those who had received the drug fared slightly better than those on the placebo arm. However, some patients in the double-blind placebo arm did improve and some patients reported side effects, which led those scientists to look more closely at what was happening in patients taking the drug tablets. This type of trial isn't available yet, but Walker and his colleague, senior author Michael W. Thase, M.D., are already planning a larger study to include 3,500 patients with PD as well another 4,000 control patients receiving other treatment. "There was evidence of benefit at 1-year from the drug but we found no effect or not very strong in the verapamilo clorhidrato 80 mg precio drug arm," Thase said in a prepared statement. "It does make the point that it would be nice not to rely on one was diagnosed paroxysmal supraventricular tachycardia drug alone, but to evaluate additional drugs in a trial setting," Thase added, referring to the possibility that many drugs may work differently from one another in combination with placebo. For the current study, however, all subjects did improve. And patients taking the drug showed a marked improvement compared with those taking the placebo arm. But because patients receiving the drug were older and less likely to have developed PD than the control patients, "there is concern that these effects may be related to a lower risk developing disease," Thase said. This was one of the first double-blind studies in United States to study the benefits of ATX102 compared with placebo, Thase noted. Still, it remains too soon to tell whether the drug is safe and effective for the primary purpose researchers studied – that is, the prevention of relapse -- or whether it's even likely to have these benefits. Walker and Thase also have plans for additional phase III trials to compare a second drug (ruthenium redux or rutilexane) against the first one in combination with a placebo riluzole to prevent relapse and see how well it has the effect of lowering risk early PD, Walker said. This will further evaluate the role of ATX102 during disease progression, Thase said. Although the drug could potentially have a broad impact on Parkinson's, it should be used with caution, according to Thase. "Patients in the rutilexane arm were very likely to have already benefited from another disease-modifying regimen, but it is unclear to what extent. This would make the drug less likely to be effective," he said, adding that it's also important to watch out for the interaction of rutilexane with antiglutaminergic agents divalproex sodium (Depakote) and topiramate (Topamax), which are also used in riluzole. "These can have a detrimental impact on the efficacy of rutilexane." Follow Live Science @livescience, Facebook & Google+. Original article on Live Science.

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